The purpose of the study is to identify a possibly novel mutation in an individual with early onset osteoarthritis. The purpose of this study is to learn the effects of synovial fluid, a clear thick joint lubricant, on joint cartilage tissue and the development of osteoarthritis.
The primary aim of the study is to see if a single wrist injection intra-articular of dexamethasone at the time of treatment will reduce the incidence of early-onset of post traumatic osteoarthritis. The purpose of this study is to determine if hydroxychloroquine is safe and effective for the prevention of a future onset of rheumatoid arthritis RA in individuals who have elevations of an autoantibody, anti-cyclic citrullinated peptide anti-CCP.
The primary purpose of this study is to describe the utilization and findings on magnetic resonance imaging MRI of the hands and feet in patients with seronegative rheumatoid arthritis RA based on the ACR or classification criteria compared to the findings seen in patients with seropositive disease RF or ACPA positive.
The purpose of this pilot study is to analyze the effectiveness of a new ultrasound microvessel imaging technology for evaluation of synovitis in patients with rheumatoid arthritis. The purpose of this study is to collect clinical and biological measures to develop an Artificial Intelligence based algorithm and clinical decision support tool to predict the week response to adalimumab, a tumor necrosis factor receptor antagonist in adults with a clinical diagnosis of rheumatoid arthritis.
Tightrope arthroplasty and ligament reconstruction with tendon interposition LRTI are both acceptable treatment options for painful arthritis at the thumb carpometacarpal joint. Advocates of the tightrope arthroplasty often cite early postoperative mobilization as a benefit to using this technique over alternative procedures.
However, early postoperative rehabilitation protocols are used following the LRTI technique at our institution as well. Our study aims to clarify whether early mobilization following LRTI results in different short-term outcomes compared to tightrope arthroplasty.
The purpose of this study is to evaluate the safety and feasibility of concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management CAM surgical procedure, and to determine pain relief, disease progression and range of motion in patients with osteoarthritis of the shoulder. The anticipated time on study drug is up to 5 years.
Study is a double-blind, randomized, placebo controlled, dose escalating study. The purpose of this post-marketing study is to compare the safety of tofacitinib versus tumor necrosis factor inhibitor with respect to major cardiovascular adverse events and malignancies, excluding non-melanoma skin cancers, when given to subjects with rheumatoid arthritis. Other safety events, including non-melanoma skin cancers, hepatic events, infections, and effectiveness parameters will be collected and evaluated in the study.
Corticosteroid injections are commonly used for the symptomatic treatment of knee osteoarthritis. Common practice is to inject the joint with a combination of corticosteroid and local anesthetic, with the rationale of providing longer duration pain relief with the corticosteroid and immediate, though short duration relief with the anesthetic.
However, multiple in vitro and animal studies have shown that local anesthetic may be harmful to chondrocytes. Despite this data, use of intra-articular anesthetic remains widespread. Many clinicians believe incorporating the anesthetic is important because it can provide immediate pain relief and facilitate patient confidence in the treatment program. However, there is The purpose of this study is to assess and compare regenerative injection therapies such as bone marrow aspiration and concentration BMAC and platelet rich plasma PRP for osteoarthritis.
The purpose of this study is to determine if a treatment based on the combination of platelet rich plasma and HA obtained with the A-CP HA Kit is statistically superior to a saline placebo or HA alone in terms of Improvement of OA-related symptoms between baseline D0 and Month 6, and reduction of pain at walking between baseline D0 and Month 6. Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases.
In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions. What is Osteoarthritis? O steoarthritis, also known as OA, is a degenerative joint disease and the most common type of arthritis. Match to Osteoarthritis Clinical Trials Access to cutting-edge treatments Latest clinical trials Find trials in your area.
Start Matching. What Causes Osteoarthritis? Age Osteoarthritis becomes more common as age advances. Obesity Joints suffer more strain if they are exposed to excessive body weight.
Gender The condition is more common in postmenopausal women than men of similar age. Genetics Studies have shown that osteoarthritis is more prevalent in siblings, which points to a hereditary component. Work or Hobbies Certain professional fields have greater exposure to joint wear than others. Previous Joint Injury Previous injuries, fractures, or infections can predispose the joint to suffer greater cartilage degradation. How is Osteoarthritis Diagnosed? Treating Osteoarthritis. Some of these medications include: Acetaminophen or paracetamol : this is the most commonly used painkiller for osteoarthritis, and it works for mild to moderate cases.
These are also used for mild to moderate cases, but they have a higher rate of side effects, such as gastrointestinal symptoms. They can also be taken during short periods of time when symptoms flare up, returning to acetaminophen when they improve.
NSAIDs can also be used topically. Glucocorticoids : these can be injected into the affected joints, and provide short-term improvement. They include hydrocortisone, and recent research has suggested triamcinolone could also be effective.
Duloxetine : although this medication is more commonly used as an antidepressant, it has been shown to improve osteoarthritis symptoms such as pain and functional impairment.
They include arnica, capsaicin, and comfrey. Learn more about the modernization effort. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : May 28, See Contacts and Locations. Study Description. The clinical study with UMC is designed to investigate the safety in patients with mild to moderate knee osteoarthritis KOA.
This will be a dose escalation, open label, single-center study in adult with mild to moderate knee osteoarthritis. UMC is ex vivo cultured human umbilical cord tissue-derived mesenchymal stem cells product which is intended for treatment of knee osteoarthritis. Detailed Description:. MedlinePlus related topics: Osteoarthritis. FDA Resources. Arms and Interventions. Outcome Measures. Incidence of withdrawals due to Adverse Events AEs.
VAS scale range 0 to mm, with higher scores indicates greater pain intensity. A decrease in score represents a decrease in disease related pain of knee. The severity of knee OA was defined as kellgren-lawrence K-L classification criteria. Changes from baseline to post-treatment visits on the target knee for Kellgren-Lawrence K-L grading and joint space in X-ray examination results.
Eligibility Criteria. Inclusion Criteria: Ambulatory subjects with osteoarthritis of the knee with symptoms for at least 3 months, that may be taking conservative therapy e.
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